The practical, efficient, diastereoselective synthesis of (3<em>R</em>,1ʹ<em>S</em>)-3-[(1ʹ-<em>N</em>-methylamino)ethyl]pyrrolidine: A chiral side chain unit for quinolone type anti-fungal agents
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
The practical, efficient, diastereoselective synthesis of (3<em>R</em>,1ʹ<em>S</em>)-3-[(1ʹ-<em>N</em>-methylamino)ethyl]pyrrolidine: A chiral side chain unit for quinolone type anti-fungal agents
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| Creator |
Yuasa, Yoshifumi
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| Subject |
<em>N</em>-Methylaminoethylpyrrolidine
Quinolone type anti-fungal agents Chiral building block Diasteroselective hydrogenation Ru-BINAP complex catalyst |
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| Description |
1189-1193
(3<em>R</em>, 1ʹ<em>S</em>)-3-[(1ʹ-<em>N</em>-Methylamino)ethyl]pyrrolidine <strong>1</strong>, which is an important chiral building block, has been synthesized from 3-acetyl-1-benzyl-2-pyrrolidione <strong>5</strong> by diasteroselective hydrogenation using the Ru-BINAP complex as the key step, followed by hydride reduction, methanesulfonylation, inverse amination and debenzylation. |
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| Date |
2018-09-13T06:19:06Z
2018-09-13T06:19:06Z 2018-09 |
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| Type |
Article
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/45045 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-B Vol.57B(09) [September 2018]
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