Anti HIV-1 activity, anti bacterial activity and phytochemical analysis of leaf extracts from <em>Cleistanthus collinus</em> (Roxb.) Benth. ex Hook.f.
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Anti HIV-1 activity, anti bacterial activity and phytochemical analysis of leaf extracts from <em>Cleistanthus collinus</em> (Roxb.) Benth. ex Hook.f.
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| Creator |
Mohanraj, Remya
Haidar, Shoaib Nobre, Malcolm Anantan, R |
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| Subject |
<em>Cleistanthus collinus</em>
Anti- HIV 1 p24 antigen expression HPLC Antibacterial activity Phytochemicals Lymphocyte culture |
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| Description |
770-775
This study is an attempt to identify new chemical entities with anti HIV1 activity. <em>In vitro</em> anti-HIV activity of <em>Cleistanthus collinus </em>extracts was evaluated using the p24 antigen assay. A dose-dependent inhibition of the p24 antigen expression was observed and the extract was found to be efficient against HIV-1. Antibacterial activity was tested against four different bacteria employing the agar well diffusion method and the highest activity was exhibited by the chloroform and methanolic extracts of <em>C. collinus</em>. HPLC analysis of the crude extract revealed the presence of phytochemicals like Gallic acid, Chlorogenic acid, 3,4 Dihydroxy B-acid, Diadizin, p-Coumaric acid, Epi-GC Gallate, Ellagic acid, Luteoline, Hesperitin and Quercetin. This report on the anti HIV 1 activity of <em>C. collinus </em>and the results obtained from the present study suggest that the extracts could serve as a source for providing potential lead compound for drug discovery against HIV-1. |
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| Date |
2018-09-14T06:38:12Z
2018-09-14T06:38:12Z 2018-10 |
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| Type |
Article
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| Identifier |
0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/45055 |
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| Language |
en_US
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| Relation |
<strong>Int. Cl.<sup>8</sup></strong>: A61K 36/00, A61K 38/26, A61P 31/18, C07K 14/16, A01D 10/00, C07K 14/155, A61P 31/04, C07, C08, C12, A61K 39/02, A61K 39/015, A61K 39/116, A61K 39/008, A61K 39/00, C12N 5/20, C12N 5/24
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJTK Vol.17(4) [October 2018]
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