Anti-obesity potential of <em>Medohar Ark</em>: A traditional <em>Ayurvedic</em> preparation in high fat diet-induced rat model
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Anti-obesity potential of <em>Medohar Ark</em>: A traditional <em>Ayurvedic</em> preparation in high fat diet-induced rat model
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| Creator |
Laturiya, Akash A
Parmar, Komal M Prasad, Satyendra K Bhojraj, Nandini Itankar, Prakash R |
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| Subject |
<em>Crocus sativus </em>L<em>.</em>
Crocin <i>Medohar Ark</i> Obesity Lipid profile |
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| Description |
745-753
The aim of the present study was to develop a phytochemical profile of <em>Medohar Ark</em>, one of the <em>Ayurvedic</em> formulation used as a potent tool for reducing weight in obese patients and also to perform preclinical evaluation for anti-obesity activity. The physicochemical parameters such as <em>p</em>H, viscosity, specific gravity and total solid content of <em>Medohar Ark</em> marketed (MAM), <em>Medohar Ark</em> in-house (MAIH) and distilled cow urine (DCU) were performed along with phytochemical screening and chromatographic (HPTLC and HPLC) study using Crocin as a biomarker. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, sterol, carbohydrates and saponins in MAIH and MAM. The HPTLC analysis revealed that, MAIH contained 4.58 % w/w of Crocin, whereas in MAM, Crocin was not detected. However, HPLC analysis of MAIH and MAM showed that MAIH and MAM contained 4.56 % w/w and 1.23 % w/w of crocin, respectively. The pharmacological evaluation concluded that, MAIH showed better result as compared to MAM in reduction of body weight of rats in high fat diet (HFD) rat model. From the lipid profile and antioxidant evaluations of animals, it was observed that there was a significant restoration in altered lipid profile and antioxidant status of HFD induced rats treated with MAM and MAIH, which was also confirmed through histopathological studies showing very less fat deposition. The overall study concludes that the <em>Medohar Ark</em> has a significant anti-obesity activity especially in case of in-house formulation, which can be used as a major tool for obesity management in human healthcare. |
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| Date |
2018-09-14T06:53:44Z
2018-09-14T06:53:44Z 2018-10 |
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| Type |
Article
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| Identifier |
0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/45058 |
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| Language |
en_US
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| Relation |
<strong>Int. Cl.<sup>8</sup></strong>: A61K 36/00, A01D 20/25, A61K 31/00, A23P 10/35, G01N 33/92
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJTK Vol.17(4) [October 2018]
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