<em>In vivo</em> antiplasmodial activities of four Nigerian plants used singly and in polyherbal combination against <em>Plasmodium berghei</em> infection
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
<em>In vivo</em> antiplasmodial activities of four Nigerian plants used singly and in polyherbal combination against <em>Plasmodium berghei</em> infection
|
|
| Creator |
Celestina, Orabueze I
Sunday, Adesegun A Duncan, Ota A Herbert, Coker A |
|
| Subject |
Antiplasmodial
Curative activity Suppressive activity Polyherbal formulation Parasitaemia Synergistic |
|
| Description |
716-723
Methanolic extracts from 4 medicinal plants representing 4 families, used traditionally for malaria treatment in South east Nigeria were screened for their <em>in vivo</em> antimalarial activity in mice against a chloroquine (CQ)-sensitive <em>Plasmodium berghei</em> NK65, alone and in combination as polyherbal remedy. The methanolic extracts of individual plants in single and in combination (100-400 mg kg<sup>-1</sup>) were administered orally to <em>P. berghei</em>-infected mice in both early and established models of antiplasmodial studies. Survival time was determined. When used alone, extracts from the 4 plants, <em>Fadogia cienkowskii</em> (FC), <em>Lophira lanceolata</em> (LL), <em>Vernonia conferta</em> (VC) and <em>Protea madiensis</em> (PM) had statistically significant parasitaemia suppression (62.06 – 93.44 %) and curative (48.93 – 72.47 %) effects. Lower doses of the 4 individual plants constituted FLVP at a combination ratio of 1: 1: 1: 1. Polyherbal formulation (FLVP) gave statistically significant suppression and curative which ranged from 45.5 – 85.1 % and 45.5 – 74.00 %, respectively. A more general improved antimalarial recovery effect, controlled weight lost and enhanced survival rate of the test mice compared to the individual plant therapeutic effect was observed. The standard drug, CQ gave stronger curative effect 100 % parasitaemia clearance. Our study findings suggest that the 4 plants used both as monotherapy and combined polyherbal remedy showed antiplasmodial <em>in vivo</em> activities and FLVP showed a more stable recovery status. FLVP is safe up to tested dose of 4000 mg kg<sup>-1</sup>. Further studies using varying fixed ratios for FLVP could result in better and improved antimalarial formulation. |
|
| Date |
2018-09-14T07:11:28Z
2018-09-14T07:11:28Z 2018-10 |
|
| Type |
Article
|
|
| Identifier |
0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/45062 |
|
| Language |
en_US
|
|
| Relation |
<strong>Int. Cl.<sup>8</sup></strong>: A61K 36/00, A01D 20/46, A61K 39/00, A61K 31/47, A61K 31/4706, A61K 31/357
|
|
| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
|
|
| Publisher |
NISCAIR-CSIR, India
|
|
| Source |
IJTK Vol.17(4) [October 2018]
|
|