Hepatoprotective effects of <em>Ilex paraguariensis</em> St. Hilaire (Yerba mate) extract in rats
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Hepatoprotective effects of <em>Ilex paraguariensis</em> St. Hilaire (Yerba mate) extract in rats
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| Creator |
Jang, Seung-Hee
Hossain, Md. Akil Lee, Jong Suk Reza, Md. Ahsanur Lee, Sam-Pin Kang, JeongWoo Park, Seung-Chun |
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| Subject |
Hepatoprotective activity
Antioxidant activity <i>Ilex paraguariensis</i> Yerba Mate Oxidative stress |
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| Description |
707-715
<em>Ilex paraguariensis</em> St. Hilaire has been revealed as an antioxidant, diuretic, hypocholesterolemic, and obesity preventive agent. The objective of the present study was to investigate the hepatoprotective effect of <em>Ilex paraguariensis </em>70 % ethanol extract (IPEE) against carbon tetrachloride-induced liver injury in an animal model. IPEE (200 and 400 mg/kg/day) were administered to rats for 7 days prior to a single dose of CCl<sub>4</sub>. Organs were collected for biochemical, histological, and molecular study after 24 h of CCl<sub>4 </sub>application. Chromatographic analyses of IPEE were accomplished. The GGT, ALP, ALT and AST in CCl<sub>4</sub>-treated control were 9, 32, 401 and 168 % increased, correspondingly than in non-treated control. The SOD, GSH and GPx levels in IPEE-pre-treated rats were similar to non-toxicated control, but were seriously affected in CCl<sub>4</sub>-treated control. The IPEE pre-treatment reduced hepatic lesions and necrosis, and expressions of <em>PPARĪ± </em>and <em>CYP4A2</em> were recovered about 48 % by 400 mg/kg/day of IPEE-pre-treatment. We found 6 major compounds, including cynarine and chlorogenic acid, and the extract was appeared to be non-toxic in acute toxicity study. This study indicates the protective effect of IPEE against CCl<sub>4</sub>-associated liver injury by attributing its control on <em>PPARĪ±</em>, <em>CYP4A2</em> regulation, and thereby it could be an opportunistic agent. |
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| Date |
2018-09-14T07:14:52Z
2018-09-14T07:14:52Z 2018-10 |
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| Type |
Article
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| Identifier |
0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/45063 |
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| Language |
en_US
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| Relation |
<strong>Int. Cl.<sup>8</sup></strong>: A61K 36/00, A61P 1/16, C09K 15/00, Bo1J 19/16, A01D 7/31, A01D 7/54
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJTK Vol.17(4) [October 2018]
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