Biological activity of <em>Nothoscordum bivalve </em>(L.) Britton and <em>Parthenium incanum </em>Kunth extracts
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Biological activity of <em>Nothoscordum bivalve </em>(L.) Britton and <em>Parthenium incanum </em>Kunth extracts
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| Creator |
Hernández-Marín, David Alejandro
Guevara-Lara, Fidel Rivas-Morales, Catalina Verduzco-Martínez, Jorge Armando Galindo-Rodriguez, Sergio Arturo Sánchez-García, Eduardo |
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| Subject |
<i>Parthenium incanum</i>
<i>Nothoscordum bivalve</i> Cytotoxicity Antioxidant Hemolysis Coagulation |
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| Description |
699-706
Medicinal properties of <em>Nothoscordum bivalve</em> (false garlic) have not been reported, while <em>Parthenium incanum</em> (<em>mariola</em>) is used to treat stomach and liver diseases. The aim of this work was to evaluate <em>in vitro</em> different biological activities of these plants to assess their pharmacological potential. Extracts were obtained by maceration or Soxhlet sequential solvent extraction. The extracts were tested by inhibiting the growth of <em>Acinetobacter baumannii</em>, besides for the techniques of <em>Artemiasalina</em> toxicity, cytotoxicity in human erythrocytes, cytoprotective, antioxidant capacity, quantification of soluble phenols and coagulation tests. MBC´s obtained were between 7.50±0.54 and 8.50±0.54 mg/mL. Toxicity assays showed LD<sub>50</sub> from 380 to 1882 µg/mL. Cytotoxicity was between 0 and 92.98 %. Cytoprotective effect indicated 0 to 94.58 %. Antioxidant capacity levels of extracts were between 275.55±21 and 598.99±4 µmol TE/g. Soluble phenolics concentrations between 1.35±0.07 and 4.13±0.04 g GAE/100 g were observed. Regarding coagulation assays, only one <em>P. incanum</em> extract showed significant difference (p < 0.05) in the PT assay. Extracts from the sequential extraction showed less toxicity and cytotoxicity, and greater antioxidant and cytoprotective capacity; they also showed no significant prolongation in the extrinsic pathway of coagulation, and a significant (although small) prolongation in the intrinsic coagulation pathway. |
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| Date |
2018-09-14T07:18:41Z
2018-09-14T07:18:41Z 2018-10 |
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| Type |
Article
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| Identifier |
0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/45064 |
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| Language |
en_US
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| Relation |
<strong>Int. Cl.<sup>8</sup></strong>: A61K 36/00, A01D 20/00, A62B, A61, C09K 15/00, B03D 3/02, B29C 67/06, C08C 1/14, C08F 6/22, A61K 38/36, C04B 103/60
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJTK Vol.17(4) [October 2018]
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