Synthesis, characterization, anti inflammatory activity and molecular docking study of novel pyrazoline derivatives bearing chalcone backbone
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Synthesis, characterization, anti inflammatory activity and molecular docking study of novel pyrazoline derivatives bearing chalcone backbone
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| Creator |
Bhadoriya, Upendra
Jain, Dinesh Kumar |
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| Subject |
Synthesis
Chalcone Heterocycles Pyrazoline Claisen-Schmidt condensation Anti-inflammatory |
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| Description |
1315-1321
Novel pyrazoline derivatives incorporating chalcone backbone have been synthesized, characterized and evaluated for their anti-inflammatory activity. The structural features of synthesized compounds have been established using IR, <sup>1</sup>H NMR, mass spectroscopy and elemental analysis. <em>In vivo</em> anti-inflammatory activity has been measured using carrageenan induced paw edema method. Molecular docking study of synthesized compounds has also been performed using cyclooxygenase-2 (COX-II) receptor PDB ID: 4-COX. Some of the synthesized compound show remarkable anti-inflammatory potential. The compound (<em>E</em>)-1-(5-(4-chlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydropyrazol-1-yl)-3 (4methoxyphenyl)prop-2-en-1-one <strong>6h</strong> shows potent anti-inflammatory activity. The outcome of docking studies also support results of <em>in vivo</em> anti-inflammatory activity. |
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| Date |
2018-10-11T10:23:05Z
2018-10-11T10:23:05Z 2018-10 |
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| Type |
Article
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/45175 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-B Vol.57B(10) [October 2018]
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