ALDA-1 protects myocardium from reperfusion damage due to its inhibitory action on mitochondrial permeability transition
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
ALDA-1 protects myocardium from reperfusion damage due to its inhibitory action on mitochondrial permeability transition
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| Creator |
Hernández-Esquivel, Luz
Belmont, Javier Rodríguez-Zavala, José S Chávez, Edmundo |
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| Subject |
ALDA-1
Calcium Heart ischemia Heart reperfusion Mitochondria Permeability transition |
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| Description |
413-419
Reperfusion following an ischemic period represents an increased risk factor for cardiovascular morbidity and mortality. Heart reperfusion is characterized, mainly, by ventricular tachycardia, arrhythmias and a drop in blood pressure. The aim of this study was to explore the effect of the aldehyde dehydrogenase-2 agonist (ALDA-1), an inducer of the expression of the mitochondrial aldehyde dehydrogenase enzyme, on heart reperfusion damage; this is plausibly caused by the accumulation of aldehydes in the myocardium, as well as by mitochondrial permeability transition. Oxidative stress caused inhibition of cis-aconitase, increased generation of TBARs and disruption of mitochondrial DNA These adverse effects were avoided with ALDA-1 treatment. |
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| Date |
2018-11-29T05:33:54Z
2018-11-29T05:33:54Z 2018-12 |
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| Type |
Article
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| Identifier |
0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/45453 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJBB Vol.55(6) [December 2018]
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