Synthesis and characterization of pectin-6-aminohexanoic acid-magnetite nanoparticles for drug delivery
IR@NPL: CSIR-National Physical Laboratory, New Delhi
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| Title |
Synthesis and characterization of pectin-6-aminohexanoic acid-magnetite nanoparticles for drug delivery
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| Creator |
Arora, Varun
Sood, Anku Shah, Jyoti Kotnala, R. K. Jain, Tapan K. |
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| Subject |
Materials Science
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| Description |
In this study, we have synthesized magnetic nanocomposites of magnetite nanoparticles coated with 6-aminohexanoic acid and pectin (MAP). The size of the aqueous dispersion of the nanocomposites was 147 nm with a Polydispersity index (PDI) of 0.32, and the nanocomposites were stable in NaCl up to a concentration of 0.45% (w/v) after which they aggregated. The dispersion of the nanocomposites was stable in Dulbecco's Modified Eagle's medium (DMEM) in the presence of 5 and 10% fetal bovine serum (FBS). Curcumin was used as a model drug to evaluate the potential of the nanocomposites for drug delivery applications. The release behavior of curcumin from the nanocomposites showed a biphasic pattern with initial burst release followed by a slow release, and the size of the aqueous dispersion of curcumin loaded nanocomposites was 159 nm with a PDI of 0.34.
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| Publisher |
Elsevier
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| Date |
2017-11-01
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://npl.csircentral.net/2900/1/Synthesis%20and%20characterization%20of.pdf
Arora, Varun and Sood, Anku and Shah, Jyoti and Kotnala, R. K. and Jain, Tapan K. (2017) Synthesis and characterization of pectin-6-aminohexanoic acid-magnetite nanoparticles for drug delivery. Materials Science and Engineering: C , 80 ( ). pp. 243-2. ISSN 0928-4931 |
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| Relation |
http://npl.csircentral.net/2900/
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