Moonlighting Protein Glyceraldehyde-3-Phosphate Dehydrogenase: A Cellular Rapid-Response Molecule for Maintenance of Iron Homeostasis in Hypoxia.
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
View Archive Info| Field | Value | |
| Title |
Moonlighting Protein Glyceraldehyde-3-Phosphate Dehydrogenase: A Cellular Rapid-Response Molecule for Maintenance of Iron Homeostasis in Hypoxia.
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| Creator |
Malhotra, Himanshu
Kumar, Manoj Chauhan, Anoop Singh Dhiman, Asmita Chaudhary, Surbhi Patidar, Anil Jaiswal, Pallavi Sharma, Kapil Sheokand, Navdeep Raje, Chaaya Iyengar Raje, Manoj |
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| Subject |
QR Microbiology
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| Description |
Hypoxia triggers a rapid increase in iron demand to meet the requirements of enhanced erythropoiesis. The mobilization of iron stores from macrophage to plasma as holo-transferrin (Tf) from where it is accessible to erythroid precursor cells impacts iron homeostasis. Despite the immediate need for enhanced iron uptake by bone marrow cells, numerous studies have shown that transferrin receptor levels do not rise until more than 24 hours after the onset of hypoxia, suggesting the existence of heretofore unknown rapid response cellular machinery for iron acquisition in the early stages of cellular hypoxia.
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| Publisher |
Cell Physiol Biochem Press
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| Date |
2019
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| Type |
Article
PeerReviewed |
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| Relation |
https://www.cellphysiolbiochem.com/Articles/000037/
http://crdd.osdd.net/open/2356/ |
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| Identifier |
Malhotra, Himanshu and Kumar, Manoj and Chauhan, Anoop Singh and Dhiman, Asmita and Chaudhary, Surbhi and Patidar, Anil and Jaiswal, Pallavi and Sharma, Kapil and Sheokand, Navdeep and Raje, Chaaya Iyengar and Raje, Manoj (2019) Moonlighting Protein Glyceraldehyde-3-Phosphate Dehydrogenase: A Cellular Rapid-Response Molecule for Maintenance of Iron Homeostasis in Hypoxia. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 52 (3). pp. 517-531. ISSN 1421-9778
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