Genome analysis of urease positive Serratia marcescens, co-producing SRT-2 and AAC(6')-Ic with multidrug efflux pumps for antimicrobial resistance.
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
View Archive Info| Field | Value | |
| Title |
Genome analysis of urease positive Serratia marcescens, co-producing SRT-2 and AAC(6')-Ic with multidrug efflux pumps for antimicrobial resistance.
|
|
| Creator |
Srinivasan, Vijaya Bharathi
Rajamohan, Govindan |
|
| Subject |
QR Microbiology
|
|
| Description |
In this study, we present the genome sequence of Serratia marcescens SM03, recovered from a human gut in India. The final assembly consists of 26 scaffolds (4620 coding DNA sequences, 5.08 Mb, 59.6% G + C ratio) and 79 tRNA genes. Analysis identified novel genes associated with lactose utilization, virulence, P-loop GTPases involved in urease production, CFA/I fimbriae apparatus and Yersinia - type CRISPR proteins. Antibiotic susceptibility testing indicated drug tolerant phenotype and inhibition assays demonstrated involvement of extrusion in resistance. Presence of enzymes SRT-2, AAC(6')-Ic, with additional Ybh transporter and EamA-like efflux pumps signifies the genetic plasticity observed in S. marcescens SM03.
|
|
| Publisher |
Elsevier Science
|
|
| Date |
2019-07-01
|
|
| Type |
Article
PeerReviewed |
|
| Identifier |
Srinivasan, Vijaya Bharathi and Rajamohan, Govindan (2019) Genome analysis of urease positive Serratia marcescens, co-producing SRT-2 and AAC(6')-Ic with multidrug efflux pumps for antimicrobial resistance. Genomics, 111 (4). pp. 653-660. ISSN 1089-8646
|
|
| Relation |
http://crdd.osdd.net/open/2523/
|
|