Development of Transmucosal Patch Using Nanofibers
IR@NPL: CSIR-National Physical Laboratory, New Delhi
View Archive Info| Field | Value | |
| Title |
Development of Transmucosal Patch Using Nanofibers
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| Creator |
Grewal, Harleen
Dhakate, Sanjay R. Goyal, Amit K. Markandeywar, Tanmay S. Malik, Basant Rath, Goutam |
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| Subject |
Biotechnology & Applied Microbiology
Engineering (General) Materials Science |
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| Description |
In the present work we have attempted to develop a novel transmucosal patch of diclofenac sodium using electrospun polycaprolactone (PCL) nanofibers. PCL nanofibers were prepared by electrospinning techniques using different polymer concentrations. Nanofibers formulations were characterized by SEM, FTIR, drug loading, and in-vitro release study using Franz diffusion cell. Studies revealed the nanofibers fabricated from 13% PCL were fracture-free, non-beaded, and ultrafine with 120 nm diameter. Release studies demonstrated the sustained release behavior of PCL nanofibers. Nanofibers can be exploited for transmucosal drug delivery of NSAID with improved therapeutic efficacy.
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| Publisher |
Taylor & Francis
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| Date |
2012-02
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://npl.csircentral.net/3647/1/Development%20of%20Transmucosal%20Patch%20Using%20Nanofi%20bers.pdf
Grewal, Harleen and Dhakate, Sanjay R. and Goyal, Amit K. and Markandeywar, Tanmay S. and Malik, Basant and Rath, Goutam (2012) Development of Transmucosal Patch Using Nanofibers. Artificial Cells, Blood Substitutes and Biotechnology , 40 (1-2). 146-150. ISSN 1073-1199 |
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| Relation |
http://npl.csircentral.net/3647/
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