Growth, differentiation, and migration of osteoblasts on transparent Ni doped TiO2 thin films deposited on borosilicate glass
IR@NPL: CSIR-National Physical Laboratory, New Delhi
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| Title |
Growth, differentiation, and migration of osteoblasts on transparent Ni doped TiO2 thin films deposited on borosilicate glass
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| Creator |
Dhayal, Marshal
Kapoor, Renu Sistla, Pavana Goury Kant, Chander Pandey, Ravi Ranjan -, Govind Saini, Krishan Kumar Pande, Gopal |
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| Subject |
Engineering
Materials Science |
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| Description |
A simple and cost effective dip coating method was used to deposit thin films of amorphous (AM) or anatase (AN) titanium dioxide (TiO2) on borosilicate glass substrates, either with or without prior doping of TiO2 with nickel (Ni) cations by a specially designed sol gel technique. The objective of the study was to compare the physicochemical and biological properties of these films and assess their use in orthopedic implants or for in vitro cell biological studies. Analytical techniques such as XRD and XPS, in combination with ATR-FTIR and SEM revealed that only AN films, prepared by controlled heating up to 450 degrees C, irrespective of prior doping with Ni, contained significant crystalline structures of variable morphologies. This observation could be linked to the carbon and oxygen contents and the availability of functional groups in the films. Cell biological studies revealed that Ni doping of TiO2 in both AM and AN films improved the adhesion, spreading, proliferation, differentiation, and migration of MC3T3 cells. Our studies provide a new approach to prepare optically transparent metal surfaces, with tunable physicochemical properties, which could be suitable for eliciting optimal osteoinductive cell responses and permit the detailed in vitro cell biological studies of osteoblasts.
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| Publisher |
Wiley
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| Date |
2012-05
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://npl.csircentral.net/3553/1/Growth%2C%20differentiation%2C%20and%20migration%20of%20osteoblasts.pdf
Dhayal, Marshal and Kapoor, Renu and Sistla, Pavana Goury and Kant, Chander and Pandey, Ravi Ranjan and -, Govind and Saini, Krishan Kumar and Pande, Gopal (2012) Growth, differentiation, and migration of osteoblasts on transparent Ni doped TiO2 thin films deposited on borosilicate glass. Journal of Biomedical Materials Research Part A , 100A (5). pp. 1168-1178. ISSN 1549-3296 |
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| Relation |
http://npl.csircentral.net/3553/
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