Label-free detection of cardiac troponin-I using gold nanoparticles functionalized single-walled carbon nanotubes based chemiresistive biosensor
IR@NPL: CSIR-National Physical Laboratory, New Delhi
View Archive Info| Field | Value | |
| Title |
Label-free detection of cardiac troponin-I using gold nanoparticles functionalized single-walled carbon nanotubes based chemiresistive biosensor
|
|
| Creator |
-, Rajesh
Sharma, Vikash Puri, Nitin K. Singh, Rajiv K. Biradar, Ashok M. Mulchanadani, Ashok |
|
| Subject |
Applied Physics/Condensed Matter
|
|
| Description |
We report a specific and ultrasensitive, label-free chemiresistive biosensor based on mercaptopropionic acid capped gold nanoparticles (GNP) functionalized single walled carbon nanotube (SWNT) hybrid for the detection of cardiac specific biomarker troponin-I (cTnI). GNPs were attached to SWNTs through a molecular linker 1-pyrenemethylamine. The highly specific cTnI antibody was covalently immobilized on GNPs through capping agent using carbodiimide coupling reaction. The cTnI interaction to its corresponding antibody was studied with respect to changes in conductance in SWNTs channel, and a detailed field-effect transistor characteristic was delineated. The device exhibited a linear response to cTnI from 0.01 to 10 ng ml(-1).
|
|
| Publisher |
American Institute of Physics
|
|
| Date |
2013-11-11
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://npl.csircentral.net/3149/1/Label-free%20detection%20of%20cardiac%20troponin-I.pdf
-, Rajesh and Sharma, Vikash and Puri, Nitin K. and Singh, Rajiv K. and Biradar, Ashok M. and Mulchanadani, Ashok (2013) Label-free detection of cardiac troponin-I using gold nanoparticles functionalized single-walled carbon nanotubes based chemiresistive biosensor. Applied Physics Letters, 103 (20). 203703-1-203703-4. ISSN 0003-6951 |
|
| Relation |
http://npl.csircentral.net/3149/
|
|