Synthesis and characterization of iron oxide-hydroxyapatite-chitosan composite coating and its biological assessment for biomedical applications
IR@NML: CSIR-National Metallurgical Laboratory, Jamshedpur
View Archive Info| Field | Value | |
| Title |
Synthesis and characterization of iron oxide-hydroxyapatite-chitosan composite coating and its biological assessment for biomedical applications
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| Creator |
Singh, S
Singh, G Bala, N |
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| Subject |
Materials Charcterization
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| Description |
Hydroxyapatite coatings are widely employed to enhance the osseointegration ability and bioactivity of biodegradable magnesium alloys as biodegradable implants. To further enhance the efficiency of hydroxyapatite-coated magnesium alloys, iron oxide particles were used along with hydroxyapatite to produce the antimicrobial and bioactive coating via electrophoretic deposition. The coatings were integrated in a matrix of chitosan. The experiments were carried out with different iron oxide particle concentrations i.e., 1, 3 and 5 (wt. %)), respectively. The antimicrobial property was investigated in Escherichia coli and Staphylococcus aureus strains, which confirmed that the micro-organisms development was suppressed by the significant rise of iron oxide particles. Evaluation of bioactivity behavior was carried out in phosphate buffer saline for 7 days, and the composite coatings were found to enhance the apatite mineralization, as affirmed by SEM-EDX analysis. The assessment of hemocompatibility showed that the hemolysis ratio was less than 5 %, which confirms that the coatings were blood compatible in nature. The outcomes showed that hydroxyapatite-iron oxide-chitosan composite coating may be extensively utilized as an appropriate material for biomedical implant applications.
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| Publisher |
Elsevier
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| Date |
2021-01
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| Type |
Article
PeerReviewed |
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| Relation |
http:// 10.1016/j.porgcoat.2020.106011
http://eprints.nmlindia.org/8267/ |
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| Identifier |
Singh, S and Singh, G and Bala, N (2021) Synthesis and characterization of iron oxide-hydroxyapatite-chitosan composite coating and its biological assessment for biomedical applications. Progress in Organic Coatings, 150 .
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