Influence of ultrasound and magnetic field treatment time on carcinoma cell inhibition with drug carriers: an in vitro study
IR@CGCRI: CSIR-Central Glass and Ceramic Research Institute, Kolkata
View Archive Info| Field | Value | |
| Title |
Influence of ultrasound and magnetic field treatment time on carcinoma cell inhibition with drug carriers: an in vitro study
|
|
| Creator |
Sengupta, Somoshree
Khatua, Chandra Pal, Aniruddha Bodhak, Subhadip Balla, V K |
|
| Subject |
Engineering Materials
|
|
| Description |
The influence of exposing carcinoma cells to a static magnetic field (SMF) and low-intensity pulsed ultrasound (LIPUS), for different durations (15-45 min/d), in the presence of magnetic and non-magnetic drug carriers, on their in vitro inhibition is examined. Increasing the exposure time by 15 min/d decreased the culture duration by 24 h to achieve the same level of inhibition in colon (HCT116) and hepatocellular (HepG2) cells. Cell cycle analysis revealed enhanced cellular blockage in G1 and S phases with SMF + LIPUS exposure, and exposure for 45 min/d completely suppressed the S -> G2 transition. Apoptosis of both types of cells increased with SMF + LIPUS treatment time, and HepG2 cells exhibited elevated necrosis with >30 min/d exposure. HepG2 cells also had higher amounts of reactive oxygen species (seven- to eightfold) than HCT116 cells (two- to sixfold), suggesting treatment effectiveness is cell and drug carrier dependent. The accelerated cellular activities are attributed to the enhanced internalization of drug carriers as a consequence of destabilized cellular membranes caused by the SMF + LIPUS-generated mechanical and electrical stimuli. (E-mail: vamsiballa@cgcri.res.in) (C) 2020 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
|
|
| Publisher |
Elsevier
|
|
| Date |
2020-12
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://cgcri.csircentral.net/4872/1/valla.pdf
Sengupta, Somoshree and Khatua, Chandra and Pal, Aniruddha and Bodhak, Subhadip and Balla, V K (2020) Influence of ultrasound and magnetic field treatment time on carcinoma cell inhibition with drug carriers: an in vitro study. Ultrasound in Medicine and Biology, 46 (10). pp. 2752-2764. ISSN 0301-5629 |
|
| Relation |
http://cgcri.csircentral.net/4872/
|
|