Degradability and in vivo biocompatibility of doped magnesium phosphate bioceramic scaffolds
IR@CGCRI: CSIR-Central Glass and Ceramic Research Institute, Kolkata
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| Title |
Degradability and in vivo biocompatibility of doped magnesium phosphate bioceramic scaffolds
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| Creator |
Sarkar, Kaushik
Rahaman, Mofizur Agarwal, Swarnima Bodhak, Subhadip Halder, Samar Nandi, Samit Kumar Roy, Mangal |
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| Subject |
Engineering Materials
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| Description |
In the present study, degradability and in vivo biocompatibility of doped magnesium phosphate (MgP) scaffolds were evaluated. 0.5 wt% Zn, 0.5 wt% Si, and 2 wt% Sr doped MgP scaffolds were prepared with up to 47% porosity. Zn doped MgP scaffolds showed nearly 13% weight loss when immersed in SBF for 8 weeks whereas least degradation was noticed for Sr doped samples. In vitro cytocompatibility study, using MC3T3-E1, showed significantly higher cell proliferation at day 5 in a composition independent manner. When implanted in rabbit femur, micro-CT (mu-CT) results showed extensive degradation for Zn doped MgP scaffolds after 2 months while significant bone growth was noticed for both Si and Sr doped scaffolds. (C) 2019 Elsevier B.V. All rights reserved.
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| Publisher |
Elsevier
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| Date |
2020-01
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://cgcri.csircentral.net/4967/1/sarkar.pdf
Sarkar, Kaushik and Rahaman, Mofizur and Agarwal, Swarnima and Bodhak, Subhadip and Halder, Samar and Nandi, Samit Kumar and Roy, Mangal (2020) Degradability and in vivo biocompatibility of doped magnesium phosphate bioceramic scaffolds. Materials Letters, 259. Art No-126892. ISSN 0167-577X |
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| Relation |
http://cgcri.csircentral.net/4967/
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