Electro-chemical oxidation and determination of granulocytosis risk inducing drug 4-aminoantipyrine at gold electrode
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Electro-chemical oxidation and determination of granulocytosis risk inducing drug 4-aminoantipyrine at gold electrode
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| Creator |
Gowda, Jayant I
Hanabaratti, Rohini M Nandibewoor, Sharanappa T |
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| Subject |
4-Aminoantipyrine
Gold electrode Electro-oxidation Diffusion controlled process Detection limit Recovery study |
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| Description |
228-235
A voltammetric technique for electrochemical sensing and quantification of granulocytosis risk inducing metabolite of aminopyrine, 4-Aminoantipyrine (4-AAP) at gold electrode has been developed. The gold electrode shows excellent selectivity and sensitivity towards the oxidation of 4-AAP in phosphate buffer solution (PBS) of pH=3.0. It is observed from the electrochemical studies of scan rate that overall electrode process is diffusion controlled and pH effect suggests involvement of protons in electrochemical oxidation of 4-AAP. A linear current response towards the electrochemical oxidation of 4-AAP in the concentration range of 1.0 × 10<sup>-6</sup> – 2.5 × 10<sup>−5</sup> M is observed with limit of detection of 3.8 × 10<sup>-</sup><sup>8</sup> M (S/N = 3). The interference studies have shown that the gold electrode exhibited excellent selectivity in presence of large excess of interferents. The method is employed to recovery study of 4-AAP in spiked urine and serum samples. |
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| Date |
2021-02-11T06:06:25Z
2021-02-11T06:06:25Z 2021-02 |
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| Type |
Article
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| Identifier |
0975-0975(Online); 0376-4710(Print)
http://nopr.niscair.res.in/handle/123456789/56198 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-A Vol.60A(02) [February 2021]
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