2,4-Dinitrophenyl hydrazone derivatives as potent alpha amylase inhibitors
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
2,4-Dinitrophenyl hydrazone derivatives as potent alpha amylase inhibitors
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| Creator |
Yousaf, Muhammad
Hassan, Amir Ahmad, Shakeel Idrees, M Adil, M Zia, Huma Haq, Mirajul Faisal, Shah Kainat |
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| Subject |
Schiff base
2,4-dinitrophenyl hydrazone Alpha amylase activity Molecular docking |
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| Description |
277-282
In our current study thirteen new 2,4-dinitrophenyl hydrazone derivatives <strong>1–13</strong> have been evaluated for alpha amylase activity. The molecular docking results indicate that compounds potentially bind in the catalytic site of the enzyme with excellent result. <em>Molecular Operating Environment</em> (MOE) software was used for docking study. 2,4-Dinitrophenyl hydrazone <strong>1-13</strong> have been obtained under reflux conditions by reacting dinitrophenyl hydrazine in methanol with different aromatic as well as aliphatic aldehydes in the presence of acetic acid act as a catalyst. The current results have shown that compounds <strong>5</strong> (IC<sub>50 </sub>=12.16<em>µ</em>g/mL), <strong>6</strong> (IC<sub>50 </sub>=15.03<em>µ</em>g/mL), and <strong>12</strong> (IC<sub>50 </sub>=16.42 <em>µ</em>g/mL) have been found to be the more potent alpha amylase inhibitors as compared to the standard acarbose (IC<sub>50 </sub>= 42.47<em>µ</em>g/mL). These compounds may provide better leads for alpha amylase inhibitor and further assessment of these compounds can be of great help in the discovery of new antidiabetic drugs. |
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| Date |
2021-02-11T10:26:33Z
2021-02-11T10:26:33Z 2021-02 |
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| Type |
Article
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/56212 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-B Vol.60B(02) [February 2021]
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