2-Pyridone quinoline hybrids as potent antibacterial and antifungal agents
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
2-Pyridone quinoline hybrids as potent antibacterial and antifungal agents
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| Creator |
Desai, N C
Harsora, J P Mehta, H K |
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| Subject |
Quinoline
2-pyridone Antimicrobial Structure activity relationship |
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| Description |
261-266
An efficient synthetic strategy for the synthesis of 6-amino-1-(((2-chloroquinolin-3-yl)methylene)amino)-2-oxo-4-(aryl)-1,2-dihydropyridine-3,5-dicarbonitriles is well described in this paper. Structures of synthesized compounds have been identified by standard spectroscopic techniques like <sup>1</sup>H NMR, <sup>13</sup>C NMR, IR and mass spectroscopy. Results of the biological activity reveals that electron withdrawing groups and presence of –OH group on <em>meta</em> position play a significant role for the increment in the antibacterial and antifungal activities respectively of <strong>3a-j</strong>. In the present study, it has been observed that compounds <strong>3i</strong> and <strong>3e</strong> are the most active antimicrobials. |
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| Date |
2021-02-11T10:33:08Z
2021-02-11T10:33:08Z 2021-02 |
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| Type |
Article
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/56215 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-B Vol.60B(02) [February 2021]
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