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1,3-Dipolar cycloaddition reactions: Synthesis and antimicrobial activity of novel 1-triazolylethylindole and 1-triazolylethylbenz[g]indole derivatives

IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)


Field	Value

Creator	Bhovi, Manjunath G Gadaginamath, Guru S

Date	2010-05-31T04:57:30Z 2010-05-31T04:57:30Z 2005-05

Identifier	0975-0983(Online); 0376-4699(Print) http://hdl.handle.net/123456789/9101

Description	1068-1073 Indole azide <b style="">4</b> and benz[g]indole azide <b style="">12</b> are reacted separately with dimethyl acetylenedicarboxylate to secure the desired 1-[4,5-dimethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole <b style="">5</b> and 1-[4,5-dimethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylbenz[g]indole <b style="">13,</b> respectively. The reaction of indole azide <b style="">4</b> and benz[g]indole azide <b style="">12</b> with ethyl propiolate has been found to be regiospecific and produce only the 1-[4-ethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole <b style="">6</b> and 1-[4-ethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylbenz[g]indole <b style="">14,</b> respectively. Indole azide <b style="">4</b> is also reacted with ethyl phenylpropolate to secure two isomeric products 1-[4-ethoxycarbonyl-5-phenyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole <b style="">8</b> and 1-[4-phenyl-5-ethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole <b style="">9</b>. All these newly synthesised compounds are screened for their antimicrobial activities.

Language	en_US

Publisher	CSIR

Relation	<b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D 209/04</b>

Source	IJC-B Vol.44B(05) [May 2005]

Title	1,3-Dipolar cycloaddition reactions: Synthesis and antimicrobial activity of novel 1-triazolylethylindole and 1-triazolylethylbenz[g]indole derivatives

Type	Article