Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Creator |
Joshi, GV
Kevadiya, BD Bajaj, HC |
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| Subject |
Pharmacology & Pharmacy
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| Description |
Aim: The objective of this work was to illustrate the suitability of montmorillonite (MMT) as a drug delivery carrier, by developing a new clay drug composite of ranitidine hydrochloride (RT) intercalated in MMT. Methods: The MMT RT composite was prepared by ion-exchange process. X-ray diffraction and Fourier transform infrared spectra were employed to confirm the intercalation of RT in the MMT interlayers. The prepared MMT RT hybrid was coated with cationic polymer Eudragit (R) E-100 by oil-in-water solvent evaporation method. The release processes of RT from MMT RT and MMT RT/Eudragit (R) E-100 were monitored under in vitro condition in the gastric fluid. Results: X-ray diffraction and Fourier transform infrared spectra analysis indicated the intercalation of RT molecules within the clay lattice. The in vitro release studies showed that MMT RT released RT in a controlled manner. In the case of MMT RT/Eudragit (R) E-100, both the release rate and the release percentages noticeably increased in the presence of Eudragit (R) E-100, because of its effective exchange with intercalated RT molecules. The release kinetics followed parabolic diffusion mechanism. Conclusion: MMT has great potential as a drug delivery carrier with various scenarios. The dosage of the MMT RT/Eudragit (R) E-100 can be in the tablet form. The hybrid material and polymer-coated hybrids are microparticles.
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| Publisher |
TAYLOR & FRANCIS INCPHILADELPHIA325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
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| Date |
2011-09-20T12:03:12Z
2011-09-20T12:03:12Z 2010 |
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| Type |
Article
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| Identifier |
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
0363-9045 http://hdl.handle.net/123456789/12220 |
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| Language |
English
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