Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Creator |
Agarwal, T
Roy, S Chakraborty, TK Maiti, S |
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| Subject |
Pharmacology & Pharmacy; Chemistry
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| Description |
We demonstrate the synthesis and selective binding of two novel furan based tricyclic homo-oligopeptides to G-quadruplex and using Real Time PCR show its repressive effect on c-MYC transcription. CD spectroscopy and FRET melting studies show that these ligands can induce G-quadruplex structures in the G rich 22 mer c-MYC DNA sequence and further stabilize the structure. Using real time polymerase chain reaction we observed that up to 70% downregulation of c-MYC transcripts upon ligand treatment in HeLa cells. (C) 2010 Elsevier Ltd. All rights reserved.
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| Publisher |
PERGAMON-ELSEVIER SCIENCE LTDOXFORDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
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| Date |
2011-09-20T12:07:07Z
2011-09-20T12:07:07Z 2010 |
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| Type |
Article
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| Identifier |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
0960-894X http://hdl.handle.net/123456789/13107 |
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| Language |
English
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