Metadata of CSIR Papers
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| Creator |
Chauhan, G
Spurgeon, CJ Tabassum, R Bhaskar, S Kulkarni, SR Mahajan, A Chavali, S Kumar, MVK Prakash, S Dwivedi, OP Ghosh, S Yajnik, CS Tandon, N Bharadwaj, D Chandak, GR |
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| Subject |
Endocrinology & Metabolism
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| Description |
OBJECTIVE-Common variants in PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, 1GF2BP2, and CDKAL1 genes have been shown to be associated with type 2 diabetes in European populations by genome-wide association studies. We have studied the association of common variants in these eight genes with type 2 diabetes and related traits in Indians by combining the data from two independent case-control studies RESEARCH DESIGN AND METHODS-We genotyped eight single nucleotide polymorphisms (PPARG-rs1801282, KCNJ11-rs5219, TCF7L2-rs7903146, SLC30A8-rs13266634, HHEX-rs1111875, CDKN2A-rs10811661, IGF2BP2-rs4402960, and CDKAL1-rs10946398) in 5,164 unrelated Indians of Indo-European ethnicity, including 2,486 type 2 diabetic patients and 2,678 ethnically matched control subjects. RESULTS-We confirmed the association of all eight loci with type 2 diabetes with odds ratio (OR) ranging from 1.18 to 1 89 (P = 1 6 x 10(-3) to 4.6 x 10(-34)). The strongest association with the highest effect size was observed for TCF7L2 (OR 1.89 [95% CI 1.71-2.09], P = 4.6 x 10(-34)). We also found significant association of PPARG and TCF7L2 with homeostasis model assessment of beta-cell function (P = 6.9 x 10(-3) and 3 x 10(-4), respectively), which looked consistent with recessive and under-dominant models, respectively CONCLUSIONS-Our study replicates the association of well-established common variants with type 2 diabetes in Indians and shows larger effect size for most of them than those reported in Europeans. Diabetes 59:2068-2074, 2010
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| Publisher |
AMER DIABETES ASSOCALEXANDRIA1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
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| Date |
2011-09-20T12:07:07Z
2011-09-20T12:07:07Z 2010 |
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| Type |
Article
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| Identifier |
DIABETES
0012-1797 http://hdl.handle.net/123456789/13109 |
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| Language |
English
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