Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Creator |
Stobdan, T
Kumar, R Mohammad, G Thinlas, T Norboo, T Iqbal, M Pasha, MAQ |
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| Subject |
Respiratory System
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| Description |
Background and objective: The role of beta 2-adrenergic receptor (ADRB2) in pulmonary oxygenation has been ascertained during altitude acclimatization, physical performance and lung fluid clearance, but little is known about its association with high-altitude pulmonary oedema (HAPE), a non-cardiogenic pulmonary oedema. Methods: In a case-control study, 110 unrelated HAPE patients (HAPE-p) and 143 unrelated HAPE-resistant (HAPE-r) controls matched on age and ethnicity were used to examine the association between eight single nucleotide polymorphisms (SNP) and disease. The eight SNP including three tag-SNP were genotyped from promoter and exonic regions of ADRB2. Robust methods for predicting geneotype-phenotype interactions, for example, multidimensional reduction (MDR) and moving-window haplotype analysis were applied. Results: The haplotypes from 46A/G and 79C/G SNP of ADRB2 were associated with HAPE. The MDR model depicting disease association through genotype-genotype and genotype-phenotype interaction included SNP 46A/G, 79C/G and 523C/A. Its haplotype 46G_79C_523C was significantly overrepresented in HAPE-r (P = 0.0001; chi(2) = 14.95; OR = 4.52; 95% CI: 1.98-10.3). The global haplotype test showed significant association with HAPE (LR chi(2) = 86.69, P < 0.0001). A moving-window analysis revealed that haplotype -367C/T_46A/G_79C/G differed significantly between HAPE-p and HAPE-r (LR chi(2) = 22.5, P = 0.002). The MDR model depicted SNP 46A/G, 79C/G and 523C/A as the best combination predicting disease. Conclusions: The haplotypes of ADRB2 consisting of the SNP, 46A/G and 79C/G, have a greater power for predicting HAPE.
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| Publisher |
WILEY-BLACKWELL PUBLISHING, INCMALDENCOMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
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| Date |
2011-09-20T12:07:10Z
2011-09-20T12:07:10Z 2010 |
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| Type |
Article
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| Identifier |
RESPIROLOGY
1323-7799 http://hdl.handle.net/123456789/13130 |
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| Language |
English
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