Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Creator |
Rani, A
Jain, S Kumar, R Kumar, A |
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| Subject |
Chemistry
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| Description |
A systematic and comparative study has been made starting from a naturally-occurring chalcone nucleus to design effective antibacterial agents. The present investigation established 1,5-bis(2-hydroxyphenyl)pent-1,4-diene-3-one (1c) as a lead compound with potential against a panel of pathogenic bacterial strains, Staphylococcus (coagulase negative), Escherichia coli, Pseudomonas aeruginosa, Acenetobacter sp. and Klebsiella pneumoniae. Gentamycine and tetracycline were used as reference drugs. The mode of antibacterial action of 1c was also studied by scanning electron microscopy, which showed membrane disruption and cell lysis of the organisms during the exposure of the tested compound. In vitro toxicity tests demonstrated that all the bioactive compounds showed far less toxicity against human erythrocytes.
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| Publisher |
BUREAU SCIENTIFIC PUBLPRETORIAP O BOX 1758, PRETORIA 0001, SOUTH AFRICA
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| Date |
2011-09-20T12:07:12Z
2011-09-20T12:07:12Z 2010 |
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| Type |
Article
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| Identifier |
SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE
0379-4350 http://hdl.handle.net/123456789/13151 |
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| Language |
English
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