Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Creator |
Nejatizadeh, A
Kumar, R Stobdan, T Goyal, AK Gupta, M Tyagi, S Jain, SK Pasha, MAQ |
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| Subject |
Medical Laboratory Technology
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| Description |
Objectives: Aldosterone synthase produces aldosterone, which regulates electrolytes and thereby blood pressure. Polymorphisms in aldosterone-synthase gene (CYP11B2) may associate with heterogeneous aldosterone production and hypertension. Hence, we investigated -344T/C, Iw/Ic polymorphisms of CYP1182, plasma renin activity (PRA) and aldosterone concentration (PAC). Design and methods: Consecutive ethnically-matched 450 hypertensive patients and 360 controls were screened by PCR-RFLP for genotypes and haplotypes; PRA and PAC were measured. Results: The Iw/Ic polymorphism distribution differed significantly between the two groups (LRT chi(2) = 15.8, df = 2, P = 0.000). The mutant allele-Ic and genotype-Ic/Ic were overrepresented in patients (35% versus 27% and 13% versus 7%). Overrepresentation of T-Ic haplotype in patients was identified as risk haplotype (P = 0.000). Patients had significantly higher PAC and aldosterone-to-renin ratio (ARR; P = 0.000), which was Ic-allele dependent. Conclusions: The haplotype T-Ic associated with hypertension susceptibility. Correlation between Ic-allele and raised ARR likely serve in hypertension management. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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| Publisher |
PERGAMON-ELSEVIER SCIENCE LTDOXFORDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
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| Date |
2011-09-20T12:07:12Z
2011-09-20T12:07:12Z 2010 |
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| Type |
Article
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| Identifier |
CLINICAL BIOCHEMISTRY
0009-9120 http://hdl.handle.net/123456789/13152 |
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| Language |
English
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