Trends in codon and amino acid usage in human pathogen Tropheryma whipplei, the only known actinobacteria with reduced genome
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
Trends in codon and amino acid usage in human pathogen Tropheryma whipplei, the only known actinobacteria with reduced genome
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| Creator |
Das, S
Paul, S Dutta, C |
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| Subject |
Biochemical Research Methods; Computer Science, Interdisciplinary Applications
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| Description |
The factors governing codon and amino acid usages in the predicted protein-coding sequences of Tropheryma whipplei TW08/27 and Twist genomes have been analyzed. Multivariate analysis identifies the replicational-transcriptional selection coupled with DNA strand-specific asymmetric mutational bias as a major driving force behind the significant inter-strand variations in synonymous codon usage patterns in T. whipplei genes, while a residual intra-strand synonymous codon bias is imparted by a selection force operating at the level of translation. The strand-specific mutational pressure has little influence on the amino acid usage, for which the mean hydropathy level and aromaticity are the major sources of variation, both having nearly equal impact. In spite of the intracellular fife-style, the amino acid usage in highly expressed gene products of T whipplei follows the cost-minimization hypothesis. Both the genomes under study are characterized by the presence of two distinct groups of membrane-associated genes, products of which exhibit significant differences in primary and potential secondary structures as well as in the propensity of protein disorder.
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| Publisher |
IMPERIAL COLLEGE PRESSCOVENT GARDEN57 SHELTON STREET, COVENT GARDEN WC2H 9HE, ENGLAND
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| Date |
2011-09-20T12:12:02Z
2011-09-20T12:12:02Z 2006 |
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| Type |
Proceedings Paper
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| Identifier |
Proceedings of the 4th Asia-Pacific Bioinformatics Conference
1-86094-623-2 http://hdl.handle.net/123456789/14093 |
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| Language |
English
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