Consequences of mutation, selection and physicochemical properties of encoded proteins on synonymous codon usage in adenoviruses
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
Consequences of mutation, selection and physicochemical properties of encoded proteins on synonymous codon usage in adenoviruses
|
|
| Creator |
Paul, S
Das, S Dutta, C |
|
| Subject |
Biochemical Research Methods; Computer Science, Interdisciplinary Applications
|
|
| Description |
Trends in synonymous codon usage in adenoviruses have been examined through the multivariate statistical analysis on the annotated protein-coding regions of 22 adenoviral species, for which complete genome sequences are available. One of the major determinants of such trends is the G + C content at third codon positions of the genes, the average value of which varied from one viral genome to other depending on the overall mutational bias of the species. G(3S) and C-3S interacted synergistically along the first principal axis of Correspondence analysis, on the Relative Synonymous Codon Usage of adenoviral genes, but antagonistically along the second principal axis. Other major determinants of the trends are the natural selection, putatively operative at the level of translation and quite interestingly, hydropathy of the encoded proteins. The trends in codon usage, though characterized by distinct virus-specific mutational bias, do not exhibit any sign of host-specificity. Significant variations are observed in synonymous codon choice in structural and nonstructural genes of adenoviruses.
|
|
| Publisher |
IMPERIAL COLLEGE PRESSCOVENT GARDEN57 SHELTON STREET, COVENT GARDEN WC2H 9HE, ENGLAND
|
|
| Date |
2011-09-20T12:12:02Z
2011-09-20T12:12:02Z 2006 |
|
| Type |
Proceedings Paper
|
|
| Identifier |
Proceedings of the 4th Asia-Pacific Bioinformatics Conference
1-86094-623-2 http://hdl.handle.net/123456789/14094 |
|
| Language |
English
|
|