Neuromodulatory role of 5-hydroxytryptamine type 1A receptors on the excitability of Renshaw cells in the rat spinal cord
Metadata of CSIR Papers
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| Title |
Neuromodulatory role of 5-hydroxytryptamine type 1A receptors on the excitability of Renshaw cells in the rat spinal cord
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| Creator |
Gajendiran, M
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| Subject |
Neurosciences
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| Description |
Serotonin modulates neurotransmission at synapses between various spinal neurons and, thus, may either facilitate or depress the information processed in the circuits and ultimately modulate the final motor output. A possible neuromodulatory role of 5-hydroxytryptamine type IA (5-HTIA) receptors on the excitability of lumbar spinal Renshaw cells was explored in anesthetized rats spinalized at T4 level. Intravenous administration of the specific 5-HTIA agonist (2R)-(+)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT) (0.1mg/kg) decreased the Renshaw cell burst response by 20-45%. This effect was completely antagonized by the specific 5-HTIA antagonist (S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenyl-propanamide dihydrochloride [(S)-WAY 100135] (0.1mg/kg, intravenous), although this drug per se had no effect on the Renshaw cell burst response. These results suggest that 8-OH-DPAT-induced decrease in Renshaw cell burst firing was mediated by 5-HTIA receptors located either presynaptically or postsynaptically.
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| Publisher |
LIPPINCOTT WILLIAMS & WILKINSPHILADELPHIA530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
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| Date |
2011-09-20T12:12:09Z
2011-09-20T12:12:09Z 2006 |
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| Type |
Article
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| Identifier |
NEUROREPORT
0959-4965 http://hdl.handle.net/123456789/14144 |
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| Language |
English
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