RNA specific molecules: Cytotoxic plant alkaloid palmatine binds strongly to poly(A)
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
RNA specific molecules: Cytotoxic plant alkaloid palmatine binds strongly to poly(A)
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| Creator |
Giri, P
Hossain, M Kumar, GS |
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| Subject |
Chemistry, Medicinal; Chemistry, Organic
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| Description |
The cytotoxic plant alkaloid palmatine was found to bind strongly by partial intercalation to single stranded poly(A) structure with binding affinity (K-a) of (8.36 +/- 0.26) x 10(5) M-1. The binding of palmatine was characterized to be exothermic and enthalpy driven with one palmatine for every two adenine residues. On the other hand, the binding to the double stranded poly(A) has been found to be significantly weak. This study identifies poly(A) as a potential bio-target for the alkaloid palmatine and its use as a lead compound in antitumor drug screening. (C) 2006 Elsevier Ltd. All rights reserved.
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| Publisher |
PERGAMON-ELSEVIER SCIENCE LTDOXFORDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
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| Date |
2011-09-20T12:12:17Z
2011-09-20T12:12:17Z 2006 |
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| Type |
Article
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| Identifier |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
0960-894X http://hdl.handle.net/123456789/14207 |
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| Language |
English
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