Preparation of Tc-99m-labelled conjugates of ouabagenin and their biological evaluation in animal models
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
Preparation of Tc-99m-labelled conjugates of ouabagenin and their biological evaluation in animal models
|
|
| Creator |
Debnath, MC
Sarkar, BR Ganguly, S Banerjee, S |
|
| Subject |
Radiology, Nuclear Medicine & Medical Imaging
|
|
| Description |
Background Ouabagenin and its 1,19-acetonide were conjugated with nitrilotriacetic acid (NTA) and diethylenetriaminepentaacetic acid (DTPA) through their respective anhydrides. Methods The reaction mixtures were exhaustively purified by silica gel column chromatography and preparative high-performance liquid chromatography to furnish the ligands in good purity and moderate yield. These ligands were labelled with Tc-99m to produce four chelates in 90-95% yield. Of these chelates the Tc-99m-oubagenin-NTA conjugate and the corresponding acetonide exhibited appreciable myocardial uptake with respect to that of other vicinal organs in a guinea-pig model. However, all these 99mTc chelates; exhibited poor heart-to-blood ratios, which could be attributed to the absence of a 30 sugar residue in this molecule. Conclusion The result is in agreement with that previously reported in connection with radioiodinated digoxin and digoxigenin derivatives.
|
|
| Publisher |
LIPPINCOTT WILLIAMS & WILKINSPHILADELPHIA530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
|
|
| Date |
2011-09-20T12:12:18Z
2011-09-20T12:12:18Z 2006 |
|
| Type |
Article
|
|
| Identifier |
NUCLEAR MEDICINE COMMUNICATIONS
0143-3636 http://hdl.handle.net/123456789/14210 |
|
| Language |
English
|
|