Cytotoxic and apoptogenic effect of tea (Camellia sinensis var. assamica) root extract (TRE) and two of its steroidal saponins TS1 and TS2 on human leukemic cell lines K562 and U937 and on cells of CML and ALL patients
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
Cytotoxic and apoptogenic effect of tea (Camellia sinensis var. assamica) root extract (TRE) and two of its steroidal saponins TS1 and TS2 on human leukemic cell lines K562 and U937 and on cells of CML and ALL patients
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| Creator |
Ghosh, P
Besra, SE Tripathi, G Mitra, S Vedasiromoni, JR |
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| Subject |
Oncology; Hematology
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| Description |
The anticancer activity of di- and tri-terpenes and other polyphenolic compounds present in tea is already reported. We. evaluated the cytotoxic and apoptogenic effect of tea root extract (TRE) and two of its steroidal saponins named as TS1 and TS2, on human cell lines and on cells from leukemic patients. It was found that TRE, TS1 and TS2 significantly decreased cell count and that TRE caused apoptosis, as confirmed morphologically by confocal microscopy and by flow-cytometric analysis using Annexin-V FITC and propidium iodide (PI). Cell count and MTT assay in normal white blood cells (WBC) of healthy volunteers revealed that TRE produced insignificant reduction in cell count and cytotoxicity. (C) 2005 Elsevier Ltd. All rights reserved.
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| Publisher |
PERGAMON-ELSEVIER SCIENCE LTDOXFORDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
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| Date |
2011-09-20T12:12:19Z
2011-09-20T12:12:19Z 2006 |
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| Type |
Article
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| Identifier |
LEUKEMIA RESEARCH
0145-2126 http://hdl.handle.net/123456789/14217 |
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| Language |
English
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