Nutritionally induced insulin resistance in an Indian perch: a possible model for type 2 diabetes
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
Nutritionally induced insulin resistance in an Indian perch: a possible model for type 2 diabetes
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| Creator |
Barma, P
Dey, D Basu, D Roy, SS Bhattacharya, S |
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| Subject |
Multidisciplinary Sciences
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| Description |
We have developed nutritionally induced, insulin-resistant Indian perch, Anabas testudineus, a freshwater teleost which showed all the characteristics found in type 2 diabetes mellitus. Free fatty acids (FFAs) are known to be the major players in implementing insulin resistance and type 2 diabetes mellitus, an epidemic disease threatening global health. Prolong feeding of a FFA, palmitic acid, to perch induced hyperinsulinaemia, hyperglycaemia, loss of insulin sensitivity and increase in glycosylated haemoglobin (HbA(1C)). Skeletal muscle cells from FFA-treated perch showed defects in insulin signalling molecules suggesting its link to the impairment of insulin action, a situation similar to that found in insulin-resistant mammalian species and human beings. Results indicate that this nutritionally induced insulin-resistant perch could be a convenient animal model to examine the potential of therapeutic compounds, addressing the problems of insulin resistance and type 2 diabetes.
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| Publisher |
CURRENT SCIENCE ASSNBANGALOREC V RAMAN AVENUE, PO BOX 8005, BANGALORE 560 080, INDIA
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| Date |
2011-09-20T12:12:21Z
2011-09-20T12:12:21Z 2006 |
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| Type |
Article
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| Identifier |
CURRENT SCIENCE
0011-3891 http://hdl.handle.net/123456789/14235 |
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| Language |
English
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