Comparative codon and amino acid composition analysis of Tritryps-conspicuous features of Leishmania major
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
Comparative codon and amino acid composition analysis of Tritryps-conspicuous features of Leishmania major
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| Creator |
Chanda, I
Pan, A Saha, SK Dutta, C |
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| Subject |
Biochemistry & Molecular Biology; Biophysics; Cell Biology
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| Description |
Comparative analyses of codon/amino acid usage in Leishmania major, Trypanosoma brucei and Trypanosoma cruzi reveal that gene expressivity and GC-bias play key roles in shaping the gene composition of all three parasites, and protein composition of L. major only. In T. brucei and T. cruzi, the major contributors to the variation in protein composition are hydropathy and/or aromaticity. Principle of Cost Minimization is followed by T. brucei, disregarded by T. cruzi and opposed by L. major. Slowly evolving highly expressed gene-products of L. major bear signatures of relatively AT-rich ancestor, while faster evolution under GC-bias has characterized the lowly expressed genes of the species by higher GC(12)-content. (C) 2007 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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| Publisher |
ELSEVIER SCIENCE BVAMSTERDAMPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
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| Date |
2011-09-20T12:12:23Z
2011-09-20T12:12:23Z 2007 |
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| Type |
Article
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| Identifier |
FEBS LETTERS
0014-5793 http://hdl.handle.net/123456789/14252 |
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| Language |
English
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