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Synthesis of symmetrically 1,4-disubstituted piperazine-2,5-diones: a new class of antileishmanial agents

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Title Synthesis of symmetrically 1,4-disubstituted piperazine-2,5-diones: a new class of antileishmanial agents
 
Creator Hazra, A
Paira, P
Palit, P
Banerjee, S
Mondal, NB
Sahu, NR
 
Subject Chemistry, Multidisciplinary
 
Description A series of 1,4-diphenyl-2,5-dioxopiperazine derivatives were synthesised in one pot sequence. The compounds demonstrated appreciable cytotoxic activity against Leishmania donovani on both forms of the parasite, and the results suggested that some derivatives (4, 11 and 12) could be exploited as antileishmanial agents.
 
Publisher SCIENCE REVIEWS LTDST ALBANSPO BOX 314, ST ALBANS AL1 4ZG, HERTS, ENGLAND
 
Date 2011-09-20T12:12:27Z
2011-09-20T12:12:27Z
2007
 
Type Article
 
Identifier JOURNAL OF CHEMICAL RESEARCH-S
0308-2342
http://hdl.handle.net/123456789/14275
 
Language English