Atropine, a muscarinic cholinergic receptor antagonist increases serotonin, but not dopamine levels in discrete brain regions of mice
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
Atropine, a muscarinic cholinergic receptor antagonist increases serotonin, but not dopamine levels in discrete brain regions of mice
|
|
| Creator |
Kumari, A
Sen Sreetama, S Mohanakumar, KP |
|
| Subject |
Neurosciences
|
|
| Description |
We investigated the effects of atropine, a muscarinic acetylcholine (ACh) receptor antagonist, on the level of serotonin, in discrete brain regions, the nucleus raphe dorsalis (NRD), nucleus caudatus putamen (NCP), cerebral cortex and the cerebellum. Biogenic amines were assayed employing HPLC electrochemistry in these regions 30 min following different doses of atropine (5, 10, 25 mg/kg; i.p.), and at various time points (15, 30, 60, 120 min) after 25, mg/kg of the drug. The cholinergic receptor antagonist caused a dose-dependent alteration in the level of serotonin in NRD, but the increase was not dose-dependent for other regions studied. The metabolite of serotonin, 5-hydroxyindoleacetic acid was unaffected. Atropine did not affect the levels of dopamine or its metabolites dihydroxyphenyl acetic acid and homovanillic acid. The present study suggests significant effect of this antimuscarinic agent on the synthesis of serotonin in the central serotoninergic pathways, which may have clinical relevance. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
|
|
| Publisher |
ELSEVIER IRELAND LTDCLAREELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
|
|
| Date |
2011-09-20T12:12:29Z
2011-09-20T12:12:29Z 2007 |
|
| Type |
Article
|
|
| Identifier |
NEUROSCIENCE LETTERS
0304-3940 http://hdl.handle.net/123456789/14294 |
|
| Language |
English
|
|