Isolation of pure compound R/J/3 from Pluchea indica (L.) Less. and its anti-amoebic activities against Entamoeba histolytica
Metadata of CSIR Papers
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| Title |
Isolation of pure compound R/J/3 from Pluchea indica (L.) Less. and its anti-amoebic activities against Entamoeba histolytica
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| Creator |
Biswas, R
Dutta, PK Achari, B Bandyopadhyay, D Mishra, M Pramanik, KC Chatterjee, TK |
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| Subject |
Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
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| Description |
The plant Pluchea indica is known for its anti-inflammatory, anti-ulcer, anti-pyretic, hypoglycemic, diuretic and antimicrobial activities besides many other pharmacological activities. We have isolated and purified seven compounds from the methanolic root extract of this plant by column chromatography. The compounds were identified by spectroscopic analyses. The anti-amoebic activities of the pure compound R/J/3 was investigated against the HM1 strain of Entamoeba histolytica. The compound, R/J/3 showed the most pronounced anti-proliferative activity at a dose of 50 mu g/ml. It also showed a marked activity on cell lysis of trophozoites, 4 h after administration. The cell lytic activity was compared with metronidazole (5 mu g/ml) as positive control. (c) 2006 Elsevier GmbH. All rights reserved.
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| Publisher |
ELSEVIER GMBH, URBAN & FISCHER VERLAGJENAOFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
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| Date |
2011-09-20T12:12:31Z
2011-09-20T12:12:31Z 2007 |
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| Type |
Article
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| Identifier |
PHYTOMEDICINE
0944-7113 http://hdl.handle.net/123456789/14309 |
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| Language |
English
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