Role of an estrogen-upregulated 64.0-kDa uterine fluid glycoprotein in improving fertility in women
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
Role of an estrogen-upregulated 64.0-kDa uterine fluid glycoprotein in improving fertility in women
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| Creator |
Das, T
Chattopadhyay, R Ghosh, S Goswami, S Chattopadhyay, D Chakravarty, B Kabir, SN |
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| Subject |
Obstetrics & Gynecology; Reproductive Biology
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| Description |
Objective: To evaluate the significance of an estrogen-upregulated 64.0-kDa human uterine fluid (hUF) glycoprotein in relation to promotion of fertility Design: Prospective study. Setting: Department of Assisted Reproductive Biology Unit, Institute of Reproductive Medicine, Kolkata. India. Patient(s): Sixty-three women with unexplained infertility having normal ovulatory cycle with normal endocrine profile and 18 parous women. Intervention(s): Women either received no stimulation (n = 35) or were stimulated with clomiphene citrate (CC) alone (100 mg/day from day 3 to day 7; n = 56) or in combination with pure FSH (75 IU on day 3 and day 8; n = 54) and were subjected to IUI Parous women (n = 18) receiving no treatment served as control and were followed-up for spontaneous ovulation. Main Outcome Measure(s): Uterine fluid protein profile, relative intensity of 64.0-kDa protein, number of mature follicles, endometrial thickness, and pregnancy. Result(s): Expression of the 64.0-kDa protein exhibited positive correlation with prevailing estradiol levels, but the degree of the protein response to estrogen was comparatively blunted in the CC-incorporated cycles. Endometrial thickness and pregnancy outcomes correlated positively with the expression of the protein. Conclusion(s): The 64.0-kDa hUF protein perhaps plays a role in endometrial receptivity to support pregnancy. Failure of pregnancy despite documented ovulation in CC-stimulated cycles may be due to its attenuating effects on expression of the protein.
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| Publisher |
ELSEVIER SCIENCE INCNEW YORK360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
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| Date |
2011-09-20T12:12:40Z
2011-09-20T12:12:40Z 2007 |
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| Type |
Article
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| Identifier |
FERTILITY AND STERILITY
0015-0282 http://hdl.handle.net/123456789/14368 |
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| Language |
English
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