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Evaluation of the biological effect of brahmi (Bacopa monnieri Linn) extract on the biodistribution of technetium-99m radiopharmaceuticals

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Field	Value

Title	Evaluation of the biological effect of brahmi (Bacopa monnieri Linn) extract on the biodistribution of technetium-99m radiopharmaceuticals

Creator	De, K Chandra, S Misra, M

Subject	Biology

Description	Natural products have been widely used by human beings in different medical and domestic applications. However, sometimes the biological effects of these products are not fully known. We investigated the effect of the oral ingestion of Bacopa monniera Linn (Brahmi) extract (BM) on the biodistribution of the radiopharmaceuticals i.e., Tc-99m labeled ethylene dicysteine diethyl ester (Tc-99m-ECD) and Tc-99m labeled cystine dimethyl ester (Tc-99m-CDM) in female Sprague Dawley rats. The rats (n = 5) were treated with BM extract (1 ml) and 0.9% NaCl solution (control, n = 5) for 8 days. After this period, Tc-99m-ECD and Tc-99m-CDM were injected and the rats were sacrificed rapidly. The organs (brain, heart, liver, lung, spleen, muscle, kidney, intestines and urine) were isolated and radioactivity in each organ was counted. The results showed that BM extracts altered the percentage of radioactivity of Tc-99m-ECD and Tc-99m-CDM in brain, heart, liver, lung, spleen, muscle, kidney, intestines and urine with respect to control. This finding was probably an example of drug interaction with a radiopharmaceutical, and a fact that could lead to misdiagnosis of the examination in clinical practice with unexpected consequences for the patient. [Life Science Journal. 2008; 5(2): 45 - 49] (ISSN: 1097 - 8135).

Publisher	MARSLAND PRESSLANSINGPO BOX 21126, LANSING, MI 48909 USA

Date	2011-09-20T12:12:43Z 2011-09-20T12:12:43Z 2008

Type	Article

Identifier	LIFE SCIENCE JOURNAL-ACTA ZHENGZHOU UNIVERSITY OVERSEAS EDITION 1097-8135 http://hdl.handle.net/123456789/14392

Language	English