Withanolide Z, a New Chlorinated Withanolide from Withania somnifera
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
Withanolide Z, a New Chlorinated Withanolide from Withania somnifera
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| Creator |
Pramanick, S
Roy, A Ghosh, S Majumder, HK Mukhopadhyay, S |
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| Subject |
Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
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| Description |
Reverse-phase preparative HPLC analysis of the n-butanol fraction of the methanolic extract of Withania somnifera Dunal (leaves) afforded a novel chlorinated withanolide, namely withanolides Z (1), along with four known withanolides, withanolide B (2), withanolide A (3), 27-hydroxywithanolide B (4) and withaferin A (5). Their structures were elucidated by IR, MS, CD and a combination of 1 D and 2 D NMR spectral analyses. The Leishmania donovani DNA topoisomerase I inhibitory activities of the isolated compounds were determined.
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| Publisher |
GEORG THIEME VERLAG KGSTUTTGARTRUDIGERSTR 14, D-70469 STUTTGART, GERMANY
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| Date |
2011-09-20T12:22:28Z
2011-09-20T12:22:28Z 2008 |
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| Type |
Article
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| Identifier |
PLANTA MEDICA
0032-0943 http://hdl.handle.net/123456789/17968 |
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| Language |
English
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