Active pharmaceutical ingredient (api) from an estuarine fungus, Microdochium nivale (Fr.)
IR@NIO: CSIR-National Institute Of Oceanography, Goa
View Archive Info| Field | Value | |
| Creator |
Bhosale, S.H.
Patil, K.B. Parameswaran, P.S. Jagtap, T.G. |
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| Date |
2011-09-19T10:24:53Z
2011-09-19T10:24:53Z 2011 |
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| Identifier |
Journal of Environmental Biology, vol.32; 2011; 653-658
http://drs.nio.org/drs/handle/2264/3917 |
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| Description |
Various marine habitats sustain variety of bio-sources of ecological and biotech potentials. Pharmaceutical potential compound Cyclosporine A was reported from marine fungus Microdochium nivale associated with Porteresia coarctata, a marine salt marsh grass from mangrove environment distributed along the Central West Coast (CWC) of India. This study involves association of M. nivale with P. coarctata plant, fermentation conditions, purification of Cyclosporine A, chemical characterization etc. Its antifungal inhibition and MIC (Minimum inhibitory concentration) against Aspergillus strains (A. niger, A. japonicus, A. fresenii), yeasts and dermatophytes (Candida sp., Cryptococcus neoformans, Trichophyton mentagrophytes, T. tonsurans, T. violaceum, Microsporium gypsum and Fusarium sp.) were evaluated. However, the MIC against A. japonicus, C. neoformans, Candida sp. and T. tonsurans were confirmed to be as low as 12.5-25 mg disc sup(-1). The antifungal properties of Cyclosporine A against Aspergillus species, yeast and dermatophytes revealed that Cyclosporine A would be a potential compound for life threatening diseases caused by above fungi in both human and animals. Furthermore, we have reported herewith another source of Cyclosporin A derived from filamentous fungus, M. nivale. occurring in marine environment
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| Language |
en
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| Publisher |
Triveni Enterprises
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| Rights |
Copyright [2011]. All efforts have been made to respect the copyright to the best of our knowledge. Inadvertent omissions, if brought to our notice, stand for correction and withdrawal of document from this repository.
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| Subject |
drugs
fungicides Microdochium nivale marine fungus |
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| Title |
Active pharmaceutical ingredient (api) from an estuarine fungus, Microdochium nivale (Fr.)
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| Type |
Journal Article
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