Preparation, characterization and in vitro biocompatibility evaluation of poly(butylene terephthalate)/wollastonite composites
Metadata of CSIR Papers
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| Title |
Preparation, characterization and in vitro biocompatibility evaluation of poly(butylene terephthalate)/wollastonite composites
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| Creator |
Risbud, M
Saheb, DN Jog, J Bhonde, R |
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| Subject |
Engineering, Biomedical; Materials Science, Biomaterials
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| Description |
The aim of the study was to prepare composites of poly(butylene terepthalate)/wollastonite (PBT/W), evaluate their properties and in vitro biocompatibility. Composites of PET with wollastonite in two different proportions, viz. 70/30 (PW-30), 50/50 (PW-50) were prepared. The DSC studies indicate marginal changes in the melting behavior and enhanced crystallization in PBT/W composites. The mechanical properties of the composites such as tensile modulus shows remarkable improvement as a result of incorporation of wollastonite. SEM studies of fractured surfaces of impact samples showed no evidence of bonding between PET and wollastonite. Water contact angle of PW30 and PW50 was 73.7 and 78.7 degrees, respectively. In vitro biocompatibility of PW-30 was evaluated as a representative composite. Direct cell contact test did not show deleterious effects on NIH3T3 fibroblast morphology and DNA integrity indicating its compatibility. Leach out products (LOP) of PW-30 were evaluated non-toxic as tested by MTT assay. Mouse peritoneal macrophages in contact with PW-30 showed comparable expression of CD 11b/18, CD45, CD14 and B7.2 to macrophages in contact with PTFE control indicating its non-activating nature. LOP did not induce proliferation of mouse splenic lymphocytes suggesting its immune-tolerance. PW-30 also exhibited preliminary blood compatibility. These physical properties and biocompatibility of PBT/W composites show their suitability as potential biomaterials. (C) 2001 Elsevier Science Ltd. All rights reserved.
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| Publisher |
ELSEVIER SCI LTDOXFORDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
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| Date |
2011-09-24T08:39:38Z
2011-09-24T08:39:38Z 2001 |
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| Type |
Article
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| Identifier |
BIOMATERIALS
0142-9612 http://hdl.handle.net/123456789/24063 |
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| Language |
English
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