Metabolism of cyclic-di-GMP in bacterial biofilms: From a general overview to biotechnological applications
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Castiglione, Nicoletta
Stelitano, Valentina Rinaldo, Serena Giardina, Giorgio Caruso, Manuela Cutruzzolà, Francesca |
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| Date |
2011-10-31T10:33:58Z
2011-10-31T10:33:58Z 2011-10 |
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| Identifier |
0975-0967 (Online); 0972-5849 (Print)
http://hdl.handle.net/123456789/12979 |
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| Description |
423-431
Bacteria exist in nature in a planktonic single-cell state or in a sessile multicellular state, the biofilm. In the latter state, the bacterial community optimizes the cell-environment and cell to cell communication strategies. Biofilms are widely diffuse in many industrial, environmental and clinical settings and are less sensitive to treatments with antimicrobial agents compared to planktonic cells. Biofilms formed by bacterial pathogens, such as, those formed by <i style="">Pseudomonas aeruginosa</i> in immunocompromised patients, have a high impact on public health. The switch between the planktonic and the biofilm lifestyle is strictly regulated by the second messenger 3', 5'-cyclic diguanylic acid (c-di-GMP). The intracellular levels of this molecule are controlled by two classes of enzymes: diguanylate cyclases (DGC) and phosphodiesterases (PDE). In this review, we report the structural and functional data available to date on these enzymes and we summarize the possible medical, environmental and industrial biotechnological applications involving bacterial c-di-GMP metabolism. |
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| Language |
en_US
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| Publisher |
NISCAIR-CSIR, India
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Source |
IJBT Vol.10(4) [October 2011]
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| Subject |
Biofilm
Cyclic-di-GMP Inhibitors Pathogenesis PDE DGC |
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| Title |
Metabolism of cyclic-di-GMP in bacterial biofilms: From a general overview to biotechnological applications
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| Type |
Article
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