Biocatalytic route for the synthesis of active pharmaceutical diol: A greener approach
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Meena, Vachan Singh
Banerjee, U C |
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| Date |
2011-10-31T10:35:15Z
2011-10-31T10:35:15Z 2011-10 |
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| Identifier |
0975-0967 (Online); 0972-5849 (Print)
http://hdl.handle.net/123456789/12982 |
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| Description |
452-457
<i>Candida viswanathii </i>was employed for the synthesis of an active pharmaceutical diol from epoxide. Studies on the culture conditions for the production of epoxide hydrolase by <i>C. viswanathii </i>revealed that cultivation temperature of 30°C and medium <i>p</i>H 7 enhanced the enzyme production. The reaction conditions for the epoxide hydrolysis were optimized and the optimal temperature and <i>p</i>H were found to be 30°C and 8, respectively. The optimized reaction time and mixing rate were 15 h and 200 rpm, respectively. Ethanol was found to be a good co-solvent. More than 90% conversion was obtained with these optimized conditions. The product formation progress was monitored by HPLC; the product was characterized by NMR and MASS spectroscopy. |
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| Language |
en_US
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| Publisher |
NISCAIR-CSIR, India
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Source |
IJBT Vol.10(4) [October 2011]
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| Subject |
Biocatalysis
Biotransformation <i>Candida viswanathii</i> Epoxide hydrolase Phenyl glycidyl ether 3-phenoxy-1,2-propane diols |
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| Title |
Biocatalytic route for the synthesis of active pharmaceutical diol: A greener approach
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| Type |
Article
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