The El Tor Biotype of Vibrio cholerae Exhibits a Growth Advantage in the Stationary Phase in Mixed Cultures with the Classical Biotype.
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
The El Tor Biotype of Vibrio cholerae Exhibits a Growth Advantage in the Stationary Phase in Mixed Cultures with the Classical Biotype.
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| Creator |
Pradhan, Subhra
Baidya, Amit K Ghosh, Amalendu Paul, Kalidas Chowdhury, Rukhsana |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Vibrio cholerae strains of the O1 serogroup that typically cause epidemic cholera can be classified into two
biotypes, classical and El Tor. The El Tor biotype emerged in 1961 and subsequently displaced the classical
biotype as a cause of cholera throughout the world. In this study we demonstrate that when strains of the El
Tor and classical biotypes were cocultured in standard LB medium, the El Tor strains clearly had a competitive
growth advantage over the classical biotype starting from the late stationary phase and could eventually take
over the population. The classical biotype produces extracellular protease(s) in the stationary phase, and the
amounts of amino acids and small peptides in the late stationary and death phase culture filtrates of the
classical biotype were higher than those in the corresponding culture filtrates of the El Tor biotype. The El Tor
biotype cells could utilize the amino acids more efficiently than the classical biotype under the alkaline pH of
the stationary phase cultures but not in medium buffered to neutral pH. The growth advantage of the El Tor
biotype was also observed in vivo using the ligated rabbit ileal loop and infant mouse animal models.
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| Publisher |
American Society for Microbiology
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/36/4/JOURNAL_OF_BACTERIOLOGY_192(_4_);2010[122].pdf
Pradhan, Subhra and Baidya, Amit K and Ghosh, Amalendu and Paul, Kalidas and Chowdhury, Rukhsana (2010) The El Tor Biotype of Vibrio cholerae Exhibits a Growth Advantage in the Stationary Phase in Mixed Cultures with the Classical Biotype. Journal of Bacteriology, 192. pp. 955-963. |
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| Relation |
htpp://dx.doi.org/10.1128/JB.01180-09
http://www.eprints.iicb.res.in/36/ |
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