Increased Chromosome Aberration Frequencies in the Bowen’s Patients Compared to Non-Cancerous Skin Lesions Individuals Exposed to Arsenic
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Increased Chromosome Aberration Frequencies in the Bowen’s Patients Compared to Non-Cancerous Skin Lesions Individuals Exposed to Arsenic
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| Creator |
Ghosh, Pritha
Banerjee, Mayukh De Chaudhuri, Sujata Das, Jayanta K Sarma, Nilendu Basu, Arindam Giri, Ashok K |
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| Subject |
Molecular & Human Genetics
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| Description |
Cytogenetic biomarkers are essential for assessing environmental exposure that can predict adverse human health effects such
as cellular damage. Chromosomal aberrations are the most important cytogenetic end-points successfully used for the cancer risk
assessment of populations occupationally or environmentally exposed to different toxic chemicals. Previous reports suggest that,
increased frequency of chromosomal aberration (CA), in peripheral blood lymphocytes, is a predictor of cancer. Arsenic is a
paradoxical human carcinogen, clastogen and aneugen. Despite of exposure at similar extent, only 15–20% of individuals show
arsenic induced skin lesions including Bowen’s disease (BD). Previously we have reported the significant increase in CA in the
individuals with arsenic induced skin lesions when compared to individuals without any skin lesions, drinking arsenic contaminated
water at similar extent. Presently, a matched case-control study was performed to examine whether biomarkers such as chromosomal
aberrations can predict the development of arsenic induced Bowen’s (in situ carcinoma) diseases. Chromosomal aberrations (both
chromosome and chromatid types) and mitotic index were analyzed from the lymphocytes of 25 cases of Bowen’s patient which was
compared to matched control from the individuals with arsenic induced non-cancerous skin lesions such as raindrop pigmentation,
keratosis of palm and sole, hypo and hyper pigmentation. Chromosomal aberrations/cell, chromosome type aberrations and total
percentage of aberrant cells were significantly higher in cases compared to control (p < 0.01). These results suggest that chromosomal
aberrations can be used for cancer risk assessment of the population exposed to arsenic through drinking water.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/39/1/Bowen's_paper_Pritha.pdf
Ghosh, Pritha and Banerjee, Mayukh and De Chaudhuri, Sujata and Das, Jayanta K and Sarma, Nilendu and Basu, Arindam and Giri, Ashok K (2007) Increased Chromosome Aberration Frequencies in the Bowen’s Patients Compared to Non-Cancerous Skin Lesions Individuals Exposed to Arsenic. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 632. pp. 104-110. |
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| Relation |
http://dx.doi.org/10.1016/j.mrgentox.2007.05.005
http://www.eprints.iicb.res.in/39/ |
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