Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Melatonin promotes angiogenesis during protection and healing of
indomethacin-induced gastric ulcer: role of matrix
metaloproteinase-2
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| Creator |
Ganguly, Krishnendu
Sharm, Anamika Vivek Reiter, Russel J Swarnakar, Snehasikta |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
Matrix metalloproteinase (MMP)-2 is considered as a crucial
regulator of angiogenesis, a process of new blood vessel formation. We
reported previously that melatonin (N-acetyl-5-methoxy tryptamine), an
antioxidant and anti-inflammatory agent, prevents indomethacin-induced
gastric ulcers. Herein, we investigated the effect of melatonin on MMP-2-
mediated angiogenesis during gastroprotection. Angiogenic properties of
melatonin were tested in both rat corneal micropocket assay and in mouse
model of indomethacin-induced gastric lesions. Melatonin augmented
angiogenesis that was associated with amelioration of MMP-2 expression
and activity and, upregulation of vascular endothelial growth factor (VEGF)
in rat cornea. Melatonin prevented gastric lesions by promoting angiogenesis
via upregulation of VEGF followed by over-expression ofMMP-2. Similarly,
healing of gastric lesions was associated with early expression of VEGF
followed by MMP-2. In addition, upregulation of MMP-2 was parallel to
MMP-14 and inverse to tissue inhibitor of metalloprotease (TIMP)-2
expression during gastroprotection. Our data demonstrated that melatonin
exerts angiogenesis through MMP-2 and VEGF over-expression during
protection and healing of gastric ulcers. This study highlights for the first
time a phase-associated regulation of MMP-2 activity in gastric mucosa and
an angiogenic action of melatonin to rescue indomethacin-induced
gastropathy.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/90/1/JOURNAL_OF_PINEAL_RESEARCH_49(2)130%2D140;2010[38].pdf
Ganguly, Krishnendu and Sharm, Anamika Vivek and Reiter, Russel J and Swarnakar, Snehasikta (2010) Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2. Journal of Pineal Research, 49 (2). pp. 130-140. |
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| Relation |
http://dx.doi.org/10.1111/j.1600-079X.2010.00776.x
http://www.eprints.iicb.res.in/90/ |
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