Bile Acid Receptor Agonist GW4064 Regulates PPAR� Coactivator-1� Expression Through Estrogen Receptor-Related Receptor �
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Bile Acid Receptor Agonist GW4064 Regulates PPAR�
Coactivator-1� Expression Through Estrogen
Receptor-Related Receptor �
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| Creator |
Banerjee, Nilanjana
Nandy, Sujay Kearns, James K Bandyopadhyay, Apurba Das, Jayanta K Majumder, Papiya Basu, Santanu Banerjee, Saptarshi Sau, Tanmoy Jyoti States, J. Christopher Giri, Ashok K |
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| Subject |
Molecular & Human Genetics
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| Description |
In West Bengal, India, at present, more than 26 million people are
exposed to arsenic through drinking water. Among them, only 15–20%
manifest arsenic-induced noncancerous, precancerous, and cancerous
skin lesions, indicating that genetic variants play important role in
arsenic susceptibility. Chronic arsenic exposure has been associated
with impairment of immune systems in the exposed individuals.
Because cytokines are important immune mediators, alteration in
expression of these gene products may lead to arsenic-specific disease
manifestations. The aim of the present work was to investigate the
association between the TNF-a 2308G>A (rs1800629) and IL10
23575T>A (rs1800890) polymorphisms and arsenic-induced dermatological
and nondermatological health outcomes. A case-control
study was conducted in West Bengal, India, involving 207 cases with
arsenic-induced skin lesions and 190 controls without skin lesions
having similar arsenic exposure. The polymorphisms were determined
using conventional PCR-sequencing method. ELISA was done to
determine the serum levels of the two cytokines tumor necrosis factor
a (TNF-a) and interleukin 10 (IL10). Associations between the
polymorphisms studied and nondermatological health effects in the
study subjects were determined from our epidemiological survey data.
Individuals with GA/AA (2308 TNF-a) and TA/AA (23575 IL10)
genotypes were at higher risk of developing arsenic-induced skin
lesions, ocular, and respiratory diseases. Also the 2308 TNF A allele
corresponded to a higher production of TNF-a, and 23575 IL10 A
allele corresponded to a lower production of IL10. Thus, the
polymorphisms studied impart significant risk toward development
of arsenic-induced dermatological and nondermatological health
effects in the chronically exposed population ofWest Bengal, India
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| Publisher |
Oxford University Press
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/120/1/TOXICOLOGICAL_CIENCES%2C121(_1)_132%2D139%2C2011_[58].pdf
Banerjee, Nilanjana and Nandy, Sujay and Kearns, James K and Bandyopadhyay, Apurba and Das, Jayanta K and Majumder, Papiya and Basu, Santanu and Banerjee, Saptarshi and Sau, Tanmoy Jyoti and States, J. Christopher and Giri, Ashok K (2011) Bile Acid Receptor Agonist GW4064 Regulates PPAR� Coactivator-1� Expression Through Estrogen Receptor-Related Receptor �. Toxicological Sciences, 121 (1). pp. 132-139. |
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| Relation |
http://dx.doi.org/10.1093/toxsci/kfr046
http://www.eprints.iicb.res.in/120/ |
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