MYC gene amplification reveals clinical association with head and neck squamous cell carcinoma in Indian patients
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
MYC gene amplification reveals clinical association with
head and neck squamous cell carcinoma in Indian patients
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| Creator |
Bhattacharya, N
Roy, A Roy, B Roychoudhury, Susanta Panda, C. K |
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| Subject |
Molecular & Human Genetics
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| Description |
Amplification of the MYC gene is reported
to be associated with the development of head
and neck squamous cell carcinoma (HNSCC). This study
is focused to analyze the correlation between MYC gene
amplification and various clinicopathological features and
outcome in a cohort of 49 dysplastic and 187 primary
head and neck lesions.
METHODS: MYC gene amplification was assessed by
differential polymerase chain reaction using primer sets
from the MYC gene as target locus and DRD2 gene as the
control locus.
RESULT: The MYC gene amplification was detected in a
total of 23.7% (56 ⁄ 236) head and neck lesions comprising
14.2% (7 ⁄ 49) dysplastic lesions and 26% (49 ⁄ 187) HNSCC
samples. The clinicopathological association study between
MYC gene amplification with the different clinical
parameters like sex, tumor stage, tumor differentiation,
lymph node status, tobacco habit and HPV 16 ⁄ 18 status
determined significant association of MYC amplification
with tumor progression (P = 0.009). Kaplan Meier analysis
revealed MYC gene has no prognostic significance on
survival in HNSCC
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| Publisher |
Blackwell Publishing
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/202/1/JOURNAL_OF_ORAL_PATHOLOGY_%26_MEDICINE%2C38(10)%2C759%2D763%2C2009[14].pdf
Bhattacharya, N and Roy, A and Roy, B and Roychoudhury, Susanta and Panda, C. K (2009) MYC gene amplification reveals clinical association with head and neck squamous cell carcinoma in Indian patients. Journal Of Oral Pathology & Medicine, 38 (10). pp. 759-763. |
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| Relation |
http://dx.doi.org/10.1111/j.1600-0714.2009.00781.x
http://www.eprints.iicb.res.in/202/ |
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